by Estrogens are best known as hormones that regulate sexual development in women, even though men also produce them. A new study now finds that a certain type of estrogen could play an additional role in the suppression of appetite.
While most of the estrogen produced by humans is synthesized in the ovaries of women, the Messenger molecules are actually produced in the body elsewhere by both men and women. In fact, around 20% of the hormones are produced by the testicles in men, while the rest from the conversion of testosterone are known as aromatase called aromatase in the brain, skin, bones and adipose tissue. Women also also produce part of their estrogen from these other sources, again thanks to the actions of the aroma.
Estrogens are also produced by cells of the central nervous system, as contained in the hypothalamus of the brain. When the hormones come from this type of production, they are referred to as neuro -locomotives. Neuro -streaks were previously examined for their role in the design of male sexual and social behaviors, but researchers from the Fujita Health University School of Medical Science in Japan decided to look at it for another reason: appetite control.
In a rodent study, you switched off the gene that encodes the aroma. This kept the genetically modified mice from synthesizing estrogens all over their body. These mice showed an increased food intake and weight gain via a control group in which the aromatase worked normally.
When the gene was switched on and the rodents’ brains again produce the aromatase, hunger was found.
In order to confirm that it was the neuro-abstrogs that had the appetite regulation effect, the researchers then examined mice where their ovaries were removed. This would mean that all estrogens were produced in their systems with other methods. In this group of mice, the researchers found that the Hypothalamus region in their brain began to increase its expression of the gene, coding aroma, which led to a reduced food intake.
It is not known whether the results of the study will be transferred to humans, and it does not confirm the possibility of adapting food intake through any kind of aromatase or neuroestrogen regulation, but it adds information to a growing part of research, the estrogen and connect appetite.
“Implecting our results that neuro -ecostrogens are likely to contribute to appetite regulation and be relevant for reducing body weight” FEBS Journal. “These observations promote our understanding of the complicated roles that neuroestrogens play when regulating metabolic functions and energy high -rise oil.”
Source: Wiley over Eurekalert
